I haven't read the Irene Adler books in years, but it seems like the closest we have for Irene? Or at least, in a canon, although I would really, really like to see Irene Adler and Mary Russell as moirails. (... no, really.)

Yeah, I can't see Moran -- although I can definitely see an editor as either moirail or kismesis, depending on the editor. :P I would put an alcoholic brother squarely into auspistice - neither lust nor liking seems appropriate.

Speaking of death: if one of your quadrant-people dies, can you get a new one, or are you left with an empty quadrant? For maximum angst, I want to give Watson a moirail in Afganistan who is killed. :P